Reviews of Physiology, Biochemistry and Pharmacology, Vol. 158
S.G. Amara, E. Bamberg, B. Fleischmann, T. Gudermann, S.C. Hebert, R. Jahn, W.J. Lederer, R. Lill, A. Miyajima, S. Offermanns, R. Zechner
Abstract Megalin and cubilin are endocytic receptors highly expressed in the endocytic apparatus of the renal proximal tubule. These receptors appear to be responsible for the tubular clearance of most proteins filtered in the glomeruli. Cubilin is a peripheral membrane protein, and therefore it does not have an endocytosis signaling sequence. It appears that megalin is responsible for internalization of cubilin and its ligands in addition to internalizing its own ligands. The proteinuria observed in megalin-deficient mice, in dogs lacking functional cubilin, and in patients with distinct mutations of the cubilin gene illustrates the importance of the receptors.
Categories:
Year:
2007
Publisher:
Springer
Language:
english
Pages:
164
ISBN 10:
3540717900
ISBN 13:
9783540717904
File:
PDF, 2.57 MB
IPFS:
,
english, 2007
This book isn't available for download due to the complaint of the copyright holder